New class
New chemical structure with a new chemical function
Specific
>20 Clinically Relevant Pathogens tested
(ARROW - screening platform panel)
No resistance
Single- and Multiple-step (>30 passages) assays has been performed
New class of
antibiotic candidate
>300 new compounds, 1 lead molecule
Hundreds of new chemical structures have been generated to create an in-house library of new drug candidates. Among more than 300 of new synthetic derivatives (all ranging 200-500Da and respecting Lipinski criteria), only one candidate was found to inhibit bacterial growth. This new chemical structure with a trichloroacetimidamide function was faced to a first optimization round and, from more than 50 derivatives, we identified DCB001 to have the highest antibacterial activity.
Specific to
Staphylococcus aureus
>20 CRP tested, S. aureus is the main target of DCB001
This heat-map shows a reduced selection of the minimal inhibitory concentration (MIC) found upon screening of tens of pathogenic strains of clinically relevant pathogens. We found a particular specificity of DCB001’s activity against Staphylococcus aureus strains, which could be a clue of a reduced patient side-effects mainly on microbiota.
No resistance observed
Different assays on multiple strains showed a low-to-no resistance/mutation rate for DCB001
Single- and multiple step assays have been performed to uncover potential strains becoming resistant to DCB001. No colony has been isolated on the plate or liquid culture to be able to grow even at high concentration (10E10 bacteria) or multiple passages (>30 passages at under-MIC).
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